EPITARGET
EPITARGET
EPITARGET

Workpackage 2: Unravelling the complex pathophysiology of epileptogenesis for preclinical development of new disease-modifying treatments

Workpackage leader

undefinedAnnamaria Vezzani

 

 Istituto di Ricerche Farmacologiche Mario Negri

Objectives of the Workpackage

The main objectives of this workpackage are the following:

 

  • To study novel molecules/pathways involved in key etiopathogenic mechanisms of epileptogenesis: We will examine the brain expression, blood levels and neuromodulatory properties of molecules involved in key etiopathogenic mechanisms of epileptogenesis using clinically relevant model systems
  • To study antiepileptogenic effects of combinatorial treatments: We will develop antiepileptogenic treatments based on combination of novel mechanism-target drugs and on novel combinations of clinically used drugs
  • To study the antiepileptogenic effects of novel combinatorial treatments using clinically used drugs
  • To develop tests for facilitating preclinical antiepileptogenic drug development to improve and foster drug discovery
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